ICI collaborative grant proposals are to be submitted on behalf of 2 or more institutions. Applications must be submitted by a team of at least 2 collaborators at each institution including one clinical collaborator or committed clinical advisor.  Other team members may include cancer or bioinformatics researchers (preferably junior faculty) postdoctoral investigators, or doctoral candidates at an NCI-designated Cancer Center, Comprehensive Cancer Center, Basic Laboratory Cancer Center, or their associated educational institution.

While funding will be awarded to a U.S. institution, work may be accomplished in collaboration with international researchers. Organizations receiving the ICI funds must be currently recognized by the Internal Revenue Service as a public charity under sections 501(c)(3) or 509(a)(1), (2), or (3) of the Internal Revenue Code. When collaborating with international researchers, the U.S. institution must certify that they will handle the funds according to the terms of U.S. laws and the grant. Provided that these requirements are met, there is NO limit to the percentage of the grant that can go toward the work of the international researchers.