SIGNAL: A population-scale resource of germline variants and accompanying somatic alterations in cancer.

We propose to build a public web resource that hosts the prevalence data of germline variants in dozens of cancer types as well as their companying somatic alterations in the same genes in the tumor. It will fill the critical gap of a public database for the dissemination and interpretation of germline variants in cancer and has the potential to become a critical reference resource for the cancer research and clinical genetics communities.