Genome Nexus: A Web Resource for the Comprehensive Annotation of Cancer Variants

To address the challenge of interpreting the functional effect of variants in cancer, Genome Nexus integrates information from various different sources, including variant effects, mutation frequencies, gene function, and clinical actionability. Genome Nexus will be accessible through a user friendly website geared towards researchers and clinicians, and it will serve other systems and websites through a web application programming interface (API). This system will benefit cancer research and the clinical oncology community.

Summary

To lower the barriers of interpreting the biological and clinical implications of variants in cancer, Genome Nexus integrates information from various sources, including variant effects, mutation frequencies, gene function, and clinical actionability. Genome Nexus is accessible through a user-friendly website geared towards researchers and clinicians. It is also geared with a high-performance web application programming interface (API) to serve the needs of real-time variant annotation in other systems and websites. For example, Genome Nexus is now being used by the cBioPortal for Cancer Genomics to help thousands of its daily users for annotating and interpreting millions of variants in its database.

Publications

Wang J, Sheridan R, Sumer SO, Schultz N, Xu D, Gao J.
G2S: a web-service for annotating genomic variants on 3D protein structures.
Bioinformatics. 2018 Jun 1;34(11):1949-1950. doi: 10.1093/bioinformatics/bty047.
PMID: 29385402

de Bruijn I, Sumer SO,  Li X, Gross B, Sheridan R, Ochoa A, Wilson M, Zhang H, Lisman A, Abeshouse A, Zhang E, Heins Z, Kandoth C,  Rodenburg S, Lukasse P, Fijneman RJA, Meijer GA,  Schultz N, Gao J
Genome Nexus: A web-service for the annotation and interpretation of genetic variants in cancer
In prep, 2020.

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